The tumour suppressor p53 is now known to be an ancient transcription factor that had already evolved interaction sites with its partner protein MDM2 at the dawn of multi-cellular eukaryotic animal life.The billion-year life history of the p53-MDM2 axis has permitted significant time for the proteins to integrate into a distinct range of cellular p
Panax ginseng-Derived Extracellular Vesicles Facilitate Anti-Senescence Effects in Human Skin Cells: An Eco-Friendly and Sustainable Way to Use Ginseng Substances
Ginseng is a traditional herbal medicine in eastern Asian countries.Most active constituents in ginseng are prepared via fermentation or organic acid pretreatment.Extracellular vesicles (EVs) are released by most organisms from prokaryotes to eukaryotes and play central roles in intra- and inter-species communications.Plants produce EVs upon exposu
Extrapolation of Thermal Sensation: Warm-Cold Stimulus Pair Elicits a Sense of Warmth Outside the Stimulus
Touching a warm stimulator with the base of the finger and a cold stimulator with the middle of the finger causes a sense of warmth at the fingertip outside the cold stimulator, revealing Extrapolation of Thermal Sensation (ETS).Although the ETS shares similarities with the Thermal Grill Illusion (TGI) regarding spatial thermal integration, the spa